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PUBLICATIONS

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2021

  • New Pd-Fe ferrocenyl antiparasitic compounds with bioactive 8-hydroxyquinoline ligands: a comparative study with their Pt-Fe analogues. F. Rivas, A. Medeiros, C. Quiroga, D. Benítez, M. Comini, E. Rodríguez-Arce, I. Machado, H. Cerecetto, D. Gambino*, Dalton Transactions 50 (2021) 1651 – 1665. DOI: 10.1039/D0DT03963B. HOT TOPIC ARTICLE

2020

  • Multi‑target heteroleptic palladium bisphosphonate complexes. M. Cipriani, S. Rostán, I. León, Z. Hong Li, J. S. Gancheff, U. Kemmerling, C. Olea Azar, S. Etcheverry, R. Docampo, D. Gambino, L. Otero. Journal of Biological Inorganic Chemistry  (2020) DOI: 10.1007/s00775-020-01779-y. 

  • Comparative high-throughput analysis of the Trypanosoma cruzi response to organometallic compounds. M. F. Mosquillo, P. Smircich, M. Ciganda, A. Lima, D. Gambino, B. Garat, L. Pérez-Díaz Metallomics (2020) Advance Article DOI: 10.1039/d0mt00030b

  • High throughput approaches to unravel the mechanism of action of a new vanadium-based compound against Trypanosoma cruzi. M. F. Mosquillo, P. Smircich, A. Lima, S. A. Gehrke, G. Scalese, I. Machado, D. Gambino, B. Garat, L. Pérez-Díaz. Bioinorganic Chemistry and Applications (2020), DOI:10.1155/2020/1634270.

  • Bactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosis. D. L. Campos, I. Machado, C. M. Ribeiro, D. Gambino, F. R. Pavan. The Journal of Antibiotics 73 (2020) 120-124.

 

​2019​

  • Lanthanide complexes with phenanthroline-based ligands: insights into cell death mechanisms by microscopy techniques. M. P. Cabral Campello, E. Palma, I. Correia, P. M. R. Paulo, A. Matos, J. Rino, J. Coimbra, J. Costa Pessoa, D. Gambino, A. Paulo, F. Marques, Dalton Transactions 46 (2019) 4611-4624. 

  • New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents. E. Rodríguez Arce, E. Putzu, M. Lapier, J. Diego Maya, C. Olea Azar, G. A. Echeverría, O. E. Piro, A. Medeiros, F. Sardi, M. Comini, G. Risi, G. Salinas, I. Correia, J. Costa Pessoa, L. Otero*, D. Gambino* Dalton Transactions 48 (2019) 7644 - 7658. 

  • Pt-Fe ferrocenyl compounds with hydroxyquinoline ligands show selective cytotoxicity on highly proliferative cells. F. Rivas, A. Medeiros, M. Comini, L. Suescun, E. Rodríguez Arce, M. Martins, T. Pinheiro, F. Marques, D. Gambino* Debbie Crans Special Issue of the Journal of Inorganic Biochemistry 199 (2019) 110779

  • Interaction with blood proteins of a ruthenium(II) nitrofuryl semicarbazone complex: effect on the antitumoral activity. B. Demoro, A. Bento-Oliveira, F. Marques, J. Costa Pessoa, L. Otero, D. Gambino*, R. F. M. de Almeida, A. I. Tomaz  Molecules Special Issue Medicinal Importance of Ruthenium Compounds. Molecules 24 (2019) 2861.

  • Exploring oxidovanadium (IV) homoleptic complexes with 8-hydroxyquinoline derivatives as prospective antitrypanosomal agents. G. Scalese, I. Machado, I. Correia, J. Costa Pessoa, L. Bilbao, L. Pérez-Diaz, D. Gambino* New Journal of Chemistry 43 (2019) 17756 – 17773.  Special Issue on Vanadium. 

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2018

  • Effect of a new anti-T. cruzi metallic compound based on Palladium. M. F. Mosquillo, L. Bilbao, F. Hernández, I. Machado, D. Gambino, B. Garat, L. Pérez-Díaz, Biometals 31 (2018) 961-974 

  • New heteroleptic oxidovanadium(V) complexes: synthesis, characterization and biological evaluation as potential agents against Trypanosoma cruzi. G. Scalese, I. Machado, C. Fontana, G. Risi, G. Salinas, L. Pérez-Díaz, D. Gambino*. Journal of Biological Inorganic Chemistry 23 (2018) 1265-1281. 

  • New heterobimetallic ferrocenyl derivatives: evaluation of their potential as prospective agents against trypanosomatid parasites and Mycobacterium tuberculosis. F. Rivas, A. Medeiros, E. Rodríguez Arce, M. Comini, C. M. Ribeiro, F. R. Pavan, D. Gambino*, Journal of Inorganic Biochemistry 187 (2018) 73-84. 

  • Trypanosoma cruzi biochemical changes and cell death induced by an organometallic platinum based compound. M. F. Mosquillo, L. Bilbao, F. Hernández, F. Tissot, D. Gambino, B. Garat, L. Pérez-Díaz. Chemical Biology & Drug Design 92 (2018) 1657-1669.  

  • Ibandronate metal complexes: solution behaviour and antiparasitic activity. B. Demoro, S. Rostán, M. Moncada, Z. Li, R. Docampo, C. Olea Azar, J. D. Maya, J. Torres, D. Gambino, L. Otero. Journal of Biological Inorganic Chemistry 23 (2018) 303-312. 

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2017

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  • Heteroleptic oxidovanadium(IV) complexes of 2-hydroxynaphtylaldimine and polypyridyl ligands against Trypanosoma cruzi and prostate cancer cells. G. Scalese, M. F. Mosquillo, S. Rostán, J. Castiglioni,  I. Alho, L. Pérez, I. Correia, F. Marques, J. Costa Pessoa*, D. Gambino*, Journal of Inorganic Biochemistry 175 (2017) 154–166.

  • The enzymatic and structural basis for inhibition of Echinococcus granulosus thioredoxin glutathione reductase by gold(I). G. Salinas, W. Gao, Y. Wang, M. Bonilla, L. Yu, A. Novikov, V. G. Virginio, H. B. Ferreira, M. Vieites, V. N. Gladyshev, D. Gambino, S. Dai. Antioxidants & Redox Signaling 27 (2017) 1491-1504.

  • Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity against Trypanosoma cruzi. E. Rodríguez Arce, I. Machado, B. Rodríguez, M. Lapier, M. C. Zúñiga, J. D. Maya, C. Olea Azar, L. Otero, D. Gambino*, Journal of Inorganic Biochemistry 170 (2017) 125-133. 

  • Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands. G. Scalese, I. Correia, J. Benítez, S. Rostán, F. Marques, F. Mendes, A. P. Matos, J. Costa Pessoa, D. Gambino*, Journal of Inorganic Biochemistry 166 (2017) 162-172. 

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2015

  • Expanding the family of heteroleptic oxidovanadium(IV) compounds with salicylaldehyde semicarbazones and polypyridyl ligands showing anti-Trypanosoma cruzi activity. G. Scalese, J. Benítez, S. Rostán, I. Correia, L. Bradford, M. Vieites, L. Minini, A. Merlino, E. L. Coitiño, E. Birriel, J. Varela, H. Cerecetto, M. González, J. Costa Pessoa, D. Gambino*, Journal of Inorganic Biochemistry 147 (2015) 116–125.

  • Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands. H. Guiset Miserachs, M. Cipriani, J. Grau, M. Vilaseca, J. Lorenzo, A. Medeiros, M. A. Comini, D. Gambino, L. Otero, V. Moreno, Journal of Inorganic Biochemistry 150 (2015) 38–47.

  • A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites. E. Rodríguez Arce, C. Sarniguet, T.S. Moraes, M. Vieites, A. I. Tomza, A. Medeiros, M. A. Comini, J. Varela, H. Cerecetto, M. González, F, Marques, M. H. García, L. Otero*, D. Gambino*, Journal of Coordination Chemistry 68 (2015) 2923-2937.

  • Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites. M. Fernández, E. Rodríguez Arce, C. Sarniguet, T. S. Morais, A. I. Tomaz, C. Olea Azar, R. Figueroa, J. Diego Maya, A. Medeiros, M. Comini, M. H. Garcia, L. Otero*, D. Gambino*, Journal of Inorganic Biochemistry 153 (2015) 306-314.

  • Aromatic amine N-oxide organometallic compounds: searching for prospective agents against infectious diseases. E. Rodríguez Arce, M. F. Mosquillo, L. Pérez-Díaz, G. A. Echeverría, O. E. Piro, A. Merlino, E. L. Coitiño, C. Maríngolo Ribeiro, C. Q. F. Leite, F. R. Pavan, L. Otero*, D. Gambino*, Dalton Transactions 44 (2015)14453-14464.

  • Exploring oxidovanadium(IV) complexes as YopH inhibitors: mechanism of action and modeling studies. P. G. Alves Martins, M. Mori, L. D. Chiaradia-Delatorre, A. C. Orbem Menegatti, A. Mascarello, B. Botta, J. Benítez, D. Gambino*, H. Terenzi*, ACS Medicinal Chemistry Letters 6 (2015) 1035-1040.

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2014

  • Solution equilibrium studies of potential anticancer metal complexes of salicylaldehyde semicarbazone and its bromo derivative. É. A. Enyedy, G. M. Bognár, N. V. Nagy, T. Jakusch, T. Kiss, D. Gambino, Polyhedron 67 (2014) 242–252.

  • New metal complexes of NNO tridentate ligands: effect of metal center and co-ligand on biological activity. I. Machado, M. Fernández, L. Becco, B. Garat, R. F. Brissos, N. Zabarska, P. Gamez, F. Marques, I. Correia, J. Costa Pessoa, D. Gambino*, Inorganica Chimica Acta 420 (2014) 39 - 46.

  • Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: molecular dynamics validation and insights into their binding modes. A. Merlino, M. Vieites, D. Gambino, E. L. Coitiño, Journal of Molecular Graphics and Modelling 48 (2014) 47-59.

  • Water soluble ruthenium complexes bearing activity against protozoan parasites. C. Sarniguet, J. Toloza, M. Cipriani, M. Lapier, M. Vieites, Y. Toledano-Magaña, J. C. García-Ramos, L. Ruiz-Azuara, V. Moreno, J. D. Maya, C. Olea Azar, D. Gambino*, L. Otero*, Biological Trace Elements Research 159 (2014) 379-392.

  • New fac-tricarbonyl rhenium(I) semicarbazone complexes: synthesis, characterization and biological evaluation. I. Machado, S. Fernández, L. Becco, B. Garat, J. S. Gancheff, A. Rey, D. Gambino*, Journal of Coordination Chemistry, 67 (2014) 1835-1850.

  • Analysis of the DNA interaction of copper compounds belonging to the Casiopeínas® antitumoral series. L. Becco, J. C. García - Ramos, L. Ruiz Azuara, D. Gambino*, B. Garat*, Biological Trace Elements Research 161 (2014) 210-215.

  • Effect of the metal ion on the anti T. cruzi activity and the mechanism of action of 5-nitrofuryl containing thiosemicarbazone metal complexes. M. Cipriani, J. Toloza, L. Bradford, E. Putzu, M. Vieites, E. Curbelo, A. I. Tomaz, B. Garat, J. Guerrero, J. S. Gancheff, J. D. Maya, C. Olea Azar, D. Gambino, L. Otero*, European Journal of Inorganic Chemistry, 27 (2014) 4677-4689. 

  • Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents. I. Machado, L. Biancolino Marino, B. Demoro, G. A. Echeverría, O. E. Piro, C. Q. F. Leite, F. R. Pavan, D. Gambino*, European Journal of Medicinal Chemistry 87 (2014) 267-273.

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2013

  • New oxidovanadium(IV) N-acylhydrazone complexes: promising antileishmanial and antitrypanosomal agents. J. Benítez, A. Cavalcanti de Queiroz, I. Correia, M. Amaral Alves, M. S. Alexandre-Moreira, E. J. Barreiro, L. Moreira Lima, J. Varela, M. González, H. Cerecetto, V. Moreno, J. Costa Pessoa, D. Gambino*, European Journal of Medicinal Chemistry 62 (2013) 20-27.

  • Oxidovanadium(IV) and dioxidovanadium(V) complexes of tridentate salicylaldehyde semicarbazones: searching for prospective antitrypanosomal agents. M. Fernández, L. Becco, I. Correia, J. Benítez, O. E. Piro, G. A. Echeverria, A. Medeiros, M. Comini, M. L. Lavaggi, M. González, H. Cerecetto, V. Moreno, J. Costa Pessoa, B. Garat, D. Gambino*, Journal of Inorganic Biochemistry, Special issue of the Journal of Inorganic Biochemistry devoted to the 11th EUROBIC,‏, 127 (2013) 150-160.

  • Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism. B. Demoro, R. F. M. de Almeida, F. Marques, C. P. Matos,  L. Otero, J. Costa Pessoa, I. Santos, A. Rodríguez, V. Moreno, J. Lorenzo, D. Gambino, A. I. Tomaz, Dalton Transactions 42 (2013) 7131-7146.

  • Searching for vanadium-based prospective agents against Trypanosoma cruzi: oxidovanadium(IV) compounds with phenanthroline derivatives as ligands. J. Benítez, I. Correia, L. Becco, M. Fernández, B. Garat, H. Gallardo, G. Conte, M. L. Kuznetsov, A. Neves, V. Moreno, J. Costa Pessoa,* D. Gambino*, Zeitschrift fuer Anorganische und Allgemeine Chemie,  Special Issue: Bioinorganic chemistry: From fundamental research to applications, 639 (2013) 1417-1425.

  • Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones. B. Demoro, M. Rossi, F. Caruso, D. Liebowitz, C. Olea-Azar, U. Kemmerling,  J. D. Maya, H. Guiset, V. Moreno, C. Pizzo, G. Mahler, L. Otero,* D. Gambino*, Biological Trace Elements Research 153 (2013) 371-381.

  • A new series of heteroleptic oxidovanadium(IV) compounds with phenanthroline-derived co-ligands: selective Trypanosoma cruzi growth inhibitors. M. Fernández, J. Varela, I. Correia, E. Birriel, J. Castiglioni, V. Moreno, J. Costa Pessoa, H. Cerecetto, M. González, D. Gambino*, Dalton Transactions, Vanadium themed issue Vanadium in Bioinorganic Chemistry 42 (2013) 11900-11911.

  • New isoniazid complexes, promising agents against Mycobacterium tuberculosis. M. Poggi, R. P. Barroso, A. J. Costa-Filho, H. Barbosa de Barros, F. R. Pavan, C. Q.F. Leite, D. Gambino*, M. H. Torre, Journal of the Mexican Chemical Society 57 (2013) 198-204.

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2012

  • Effect of complexation of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides with palladium and copper on their anti-T. cruzi activity. D. Benítez, M. L. Lavaggi, D. Gambino, M. H. Torre, H. Cerecetto, M. González, Medicinal Chemistry Research 21 (2012) 1439-1444. 

  • New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents. B. Demoro, C. Sarniguet, R. Sánchez-Delgado, M. Rossi, D. Liebowitz, F. Caruso, C. Olea-Azar, V. Moreno, A. Medeiros, M. A. Comini, L. Otero*,  D. Gambino* Dalton Transactions 41 (2012) 1534 - 1543.

  • New achievements on biological aspects of copper complexes CasiopeínasÒ: interaction with DNA and proteins and anti-Trypanosoma cruzi activity. L. Becco, A. Rodríguez, M. Elena Bravo, M. J. Prieto, L. Ruiz-Azuara, B. Garat, V. Moreno, D. Gambino*Journal of Inorganic Biochemistry 109 (2012) 49-56.

  • Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. B. Demoro, F. Caruso, M. Rossi, D. Benítez, M. Gonzalez, H. Cerecetto, M. Galizzi, L. Malayil, R. Docampo, R. Faccio, Á. W. Mombrú, D. Gambino, L. Otero, Dalton Transactions  41 (21) (2012) 6468 - 6476. Special Issue: Application of Inorganic Chemistry for non-Cancer Therapeutics.

  • Activity on Trypanosoma cruzi, erythrocytes lysis and biologically relevant physicochemical properties of Pd(II) and Pt(II) complexes of thiosemicarbazones derived from 1-indanones. D. Santos, B. Parajón Costa, M. Rossi, F. Caruso, D. Benítez, J. Varela, H. Cerecetto, M. González, M. E. Caputto, A. G. Moglioni, G. Y. Moltrasio, L. M. Finkielsztein, D. Gambino*, Journal of Inorganic Biochemistry, Special Issue ISABC, 117 (2012) 270–276.

  • Hydroxylamido/ amino acid complexes of oxovanadium(V). Toxicological study in cell culture and in a zebrafish model. Ignacio E. León, Ana L. Di Virgilio, Daniel A. Barrio, Gabriel Arrambide, D. Gambino, Susana B. Etcheverry, Metallomics 4 (2012)1287-1296.

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2011

  • Synthesis and characterization of the bistropolonato oxovanadium(IV) and (V) complexes. B. S. Parajón-Costa, E. J. Baran, J. Romero, R. Sáez-Puche, G. Arrambide, D. Gambino, Journal of Coordination Chemistry 64(2011) 57-70.

  • Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: new achievements. J. Benítez, L. Becco, I. Correia, S. Milena Leal, H. Guiset, J. Costa Pessoa, J. Lorenzo, S. Tanco, P. Escobar, V. Moreno, B. Garat, D. Gambino*, Journal of Inorganic Biochemistry 105 (2011) 303-311. 

  • Searching for novel gallium bioactive compounds: gallium(III) complexes of tridentate salicylaldehyde semicarbazone derivatives. D. Gambino*, M. Fernández, D. Santos, G. A. Etcheverría, O. E. Piro, F. R. Pavan, C. Q. F. Leite, I. Tomaz, F. Marques, Polyhedron 30 (2011) 1360-1366. 

  • In search of patterns over physicochemical properties and pharmacological activities for a set of [MCl2(Thiosemicarbazone)] complexes (M=Pt/Pd): Support for multiple mechanisms of antichagasic action excluding DNA-bonding in vivo? A. Merlino, L. Otero, D. Gambino*, E. L. Coitiño*, European Journal of Medicinal Chemistry 46 (2011) 2639-2651.

  • Synthesis, structural characterization and proapoptotic activity of 1-indanone thiosemicarbazones platinum (II) and palladium (II) complexes: Potential role as selective antileukemic agents. N. Gómez, D. Santos, R. Vázquez, L. Suescun, Á. Mombrú, M. Vermeulen, L. Finkielsztein, C. Shayo, A. Moglioni,* D. Gambino,* C. Davio*, ChemMedChem 6 (2011) 1485-1494.

  • Crystal and molecular structure of a new hydroxylamido/amino acid oxovanadium(V) complex, [VO(NH2O)2(DL-methioninato)]×H2O. O. E. Piro, G. A. Echeverría, G. Arrambide,  D. Gambino,  E. J. Baran, Zeistschrift für Naturforschung B, 66b (2011) 752-754.

  • DNA as molecular target of analogous palladium and platinum anti-Trypanosoma cruzi compounds: a comparative study. M. Vieites, P. Smircich, M. Pagano, L. Otero, F. Luane Fischer, H. Terenzi, M. J. Prieto, V. Moreno, B. Garat*, D. Gambino* Journal of Inorganic Biochemistry, Special Issue celebrating Bio-Inorganic Chemistry in Latin America 105 (2011) 1704-1711.

  • Ruthenium (II) phosphine/diimine/picolinate complexes: inorganic compounds as agents against tuberculosis. F. R. Pavan, G. V. Poelhsitz, M. I. F. Barbosa, S. R.A. Leite, A. A. Batista, J. Ellena, L. S. Sato, S. G. Franzblau, V. Moreno, D. Gambino, C. Q. F. Leite, European Journal of Medicinal Chemistry 46 (2011) 5099-5107.

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2010

  • Spectroscopic behavior and biological activity of K2[VO(O2)NTA]∙2H2O. G. Arrambide, D.A. Barrio, S.B. Etcheverry, D. Gambino, E. J. Baran, Biological Trace Elements Research 136 (2) (2010) 241-248.

  • Risedronate metal complexes potentially active against Chagas disease. B. Demoro, F. Caruso, M. Rossi, D. Benítez, M. Gonzalez, H. Cerecetto, B. Parajón-Costa, J. Castiglioni, M. Galizzi, R. Docampo, L. Otero*, D. Gambino*, Journal of Inorganic Biochemistry 104 (2010) 1252-1258.

  • Design of novel iron compounds as potential therapeutic agents against Tuberculosis. M. B. Tarallo, C. Urquiola, A. Monge, B. Parajón Costa, R. R. Ribeiro, A. J. Costa-Filho, R. C. Mercader, F. R. Pavan,  C. Q. F. Leite, M. H. Torre*, D. Gambino*, Journal of Inorganic Biochemistry 104 (2010) 1164–1170.

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2009

  • Synthesis and spectroscopic characterization of hydroxylamido/amino acid complexes of oxovanadium(V), G. Arrambide, D. Gambino, E. J. Baran. Journal of Coordination Chemistry 62(1) (2009) 63-74.

  • Design of vanadium mixed-ligand complexes as potential anti-protozoa agents, J. Benítez, L. Guggeri, I. Tomaz, G. Arrambide, M. Navarro, J. Costa Pessoa, B. Garat*, D. Gambino*. Journal of Inorganic Biochemistry, special issue dedicated to the 6th International Vanadium Symposium 103 (2009) 609-616.

  • Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs, C. Urquiola, M. Vieites, M. H. Torre, M. Cabrera, M. L. Lavaggi, H. Cerecetto, M. González, A. López de Cerain, A. Monge, P. Smircich, B. Garat. D. Gambino*, Bioorganic and Medicinal Chemistry 17 (2009) 1623-1629.

  • Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti - Trypanosoma cruzi activity, M. Vieites, L. Otero, D. Santos, C. Olea-Azar, E. Norambuena, G. Aguirre, H. Cerecetto, M. González, U. Kemmerling,  A. Morello, J. D. Maya, D. Gambino*, Journal of Inorganic Biochemistry 103 (2009) 411-418.

  • Biological effects of a complex of vanadium(V) with salicylaldehyde semicarbazone in osteoblasts in culture. Mechanism of action. J. Rivadeneira, D. Barrio, G. Arrambide, D. Gambino, L. Bruzzone, S. Etcheverry, Journal of Inorganic Biochemistry 103 (2009) 633-642.

  • Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. Insight into its mechanism of action. M. Vieites, P. Smircich, L. Guggeri, E. Marchán, A. Gómez-Barrio, M. Navarro, B. Garat, D. Gambino*, Journal of Inorganic Biochemistry 103 (2009) 1300-1306.  

  • Research of new mixed-chelate copper complexes with quinoxaline N1,N4-dioxide derivatives and alanine as ligands, potential antimycobacterial agents. M. B. Tarallo, A. J. Costa-Filho, E. D. Vieira, A. Monge, C. Q. Leite, F. R. Pavan, G. Borthagaray, D. Gambino*, M. H. Torre*, Journal of the Argentine Chemical Society 97(1) (2009) 80-89.

  • Spectroscopic Behavior and Biological Activity of K3[VO(O2)2CO3].H2O. G. Arrambide, J. Rivadeneira, S.B. Etcheverry, B.S. Parajón-Costa, D. Gambino, E. J. Baran, Biological Trace Element Research 132 (2009) 176-183.

  • A novel vanadyl complex with a polypyridyl DNA intercalator as ligand: a potential anti-protozoa and anti tumor agent. J. Benítez,  L. Guggeri, I. Tomaz, J. Costa Pessoa, V. Moreno, J. Lorenzo,  F. X. Avilés,  B. Garat, D. Gambino*, Journal of Inorganic Biochemistry 103 (2009) 1386-1394.

  • Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones. M. Pagano, B. Demoro, J. Toloza, L. Boiani, M. González, H. Cerecetto, C. Olea-Azar, E. Norambuena, D. Gambino, L. Otero, European Journal of Medicinal Chemistry 44 (2009) 4937-4943.

  • Copper (II) risedronate: the importance of structure validation on the correct solution. M. RossiB. DemoroL. OteroD. Gambino, F. CarusoActa Crystallographica Section A Foundations of Crystallography 65(a1) (2009) s287.

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2008

  • Insight into the bioreductive mode of action of antitrypanosomal 5-nitrofuryl containing thiosemicarbazones. L. Otero, J. D. Maya, A. Morello, C. Rigol, G. Barriga, J. Rodriguez, C. Folch, E. Norambuena, M. González, C. Olea Azar, H. Cerecetto*, D. Gambino*, Medicinal Chemistry 4(1) (2008) 11-17.

  • New copper-based complexes with quinoxaline N1-N4-dioxide derivatives, potential antitumoral agents. C. Urquiola, D. Gambino, M. Cabrera, M. L. Lavaggi, H. Cerecetto, M. González, A. López de Cerain, A. Monge, A. J.Costa-Filho, M. H. Torre. Journal of Inorganic Biochemistry 102 (2008) 119-126.

  • ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes. L. Otero, C. Folch, G. Barriga, C. Rigol, L. Opazo, M. Vieites, D. Gambino, H. Cerecetto, E. Norambuena, C. Olea-Azar. Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 70(3) (2008) 519-523.

  • Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents. M. Vieites, L. Otero, D. Santos, D. Gajardo, J. Toloza, R. Figueroa, E. Norambuena, C. Olea-Azar, G. Aguirre, H. Cerecetto, M. González, A. Morello, J. D. Maya, B. Garat, D. Gambino*. Journal of Inorganic Biochemistry, Special Issue dedicated to 13th ICBIC 2007, 102 (2008) 1033-1043.

  • Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having inhibitory effect on parasite-specific fumarate reductase. M. Vieites, P. Smircich, B. Parajón-Costa, J. Rodríguez, V. Galaz, C. Olea-Azar, L. Otero, G. Aguirre, H. Cerecetto, M. González, A. Gómez-Barrio, B. Garat, D. Gambino*. Journal of Biological Inorganic Chemistry 13(5) (2008) 723-735.

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2007

  • DNA conformational changes and cleavage by ruthenium (II) nitrofurylsemicarbazone complexes. L. Otero, P. Smircich, M. Vieites, M. Ciganda, P. Cardoso Severino, H. Terenzi, H. Cerecetto, D. Gambino*, B. Garat*. Journal of Inorganic Biochemistry 101 (2007) 74-79.

  • Vibrational spectra of palladium 5-nitrofuryl thiosemicarbazone complexes: experimental and theoretical study. D. Gambino*, L. Otero, M. Vieites, M. Boiani, M. González, E. J. Baran, H. Cerecetto. Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 68 (2007) 341-348.

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2006

  • Pd(thiosaccharinato)2.H2O, the first thiosaccharinato complex of a platinum-group metal. M. Vieites, D. Gambino, M. González, H. Cerecetto, S. H. Tarulli, O. V. Quinzani, E. J. Baran Journal of Coordination Chemistry 59(1) (2006) 101-106.

  • Novel Vanadyl Complexes with Quinoxaline N1,N4-Dioxide Derivatives as Potent in vitro Insulin-mimetic Compounds. P. Noblía, M. Vieites, M. H. Torre, A. J. Da Costa Filho, H. Cerecetto, M. González, M. L. Lavaggi, Y. Adachi, H. Sakurai, D. Gambino*. Journal of Inorganic Biochemistry 100(2) (2006) 281-287.

  • Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives. M. Vieites, P. Noblía, M. H. Torre, H. Cerecetto, M. L. Lavaggi, A. J. Costa Filho, A. Azqueta, A. López de Cerain, A. Monge, B. Parajón-Costa, M. González*, D. Gambino*. Journal of Inorganic Biochemistry 100(8) (2006) 1358-1367.

  • Nitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agents. L. Otero, G. Aguirre, L. Boiani, M. González, A. Denicola, C. Rigol, C. Olea-Azar, J. D. Maya, A. Morello, D. Gambino*, H. Cerecetto*. European Journal of Medicinal Chemistry 41(11) (2006) 1231-1239.

  • Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets. L. Otero, M. Vieites, L. Boiani, A. Denicola, C. Rigol, L. Opazo, C. Olea-Azar, J. D. Maya, A. Morello, R. Luise Krauth-Siegel, O. E. Piro, E. Castellano, M. González, D. Gambino*, H. Cerecetto*. Journal of Medicinal Chemistry 49 (2006) 3322-3331.

  • Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives by complexation with vanadium. C. Urquiola, M. Vieites, G. Aguirre, A. Marín, B. Solano, G. Arrambide, M. L. Lavaggi, M. H. Torre, M. González, A. Monge, D. Gambino*, H. Cerecetto*. Bioorganic Medicinal Chemistry 14 (2006) 5503-5509.

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2005

  • Vanadium(V) complexes with salicylaldehyde semicarbazone derivatives bearing in vitro anti-tumor activity toward kidney tumor cells (TK-10). Crystal structure of [VVO2(5-bromosalicylaldehyde semicarbazone)]. P.Noblía, M.Vieites, B.Parajón-Costa, E.J.Baran, H.Cerecetto, P.Draper, M.González, O.E. Piro, E.E. Castellano, A. Azqueta, A. López, A. Monge-Vega, D. Gambino*. Journal of Inorganic Biochemistry 99(2) (2005) 443-451.

  • Electrochemical and ESR study of 5-nitrofuryl-containing thiosemicarbazones antiprotozoal drugs. C. Rigol, C. Olea-Azar, F. Mendizábal, L. Otero, D. Gambino, M. González, H. Cerecetto. Spectrochimica Acta part A Molecular and Biomolecular Spectroscopy  61(13-14) (2005) 2933-2938.

  • Chemoselective hydrolysis of the iminic moiety in salicylaldehyde semicarbazone promoted by ruthenium. M.Vieites, P.Buccino, L. Otero, M.González, O.E.Piro, R.Sánchez-Delgado, C. M. Sant’Anna, E. Barreiro, H. Cerecetto*, D. Gambino*. Inorganica Chimica Acta 358(11) (2005) 3065-3074.

  • Palladium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones: spectral characterization, structural studies and cytotoxic activity. A. P. Rebolledo, M. Vieites, D. Gambino, O. E. Piro, E. E. Castellano C. L. Zani, E. S. Fagundes, L. R.S Teixeira, A. A. Batista, H. Beraldo. Journal of Inorganic Biochemistry 99(3) (2005) 698-706.

  • Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins. M.H.Torre, D. Gambino, J. Araujo, H.Cerecetto, M.González, M.L. Lavaggi, A.Azqueta, A. López de Cerain, A. Monge-Vega, U. Abram, A.J. Costa-Filho European Journal of Medicinal Chemistry 40(5) (2005) 473-483.

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2004

  • New vanadium(V) complexes with salicylaldehyde semicarbazone derivatives: Synthesis, characterization and in vitro insulin mimetic activity. Crystal structure of [VVO2(salicylaldehyde semicarbazone)]. P. Noblía, E. J. Baran, L. Otero, P. Draper, H. Cerecetto, M. González, O. E. Piro, E. E. Castellano, T. Inohara, Y. Adachi, H. Sakurai, D. Gambino*. European Journal of Inorganic Chemistry 2 (2004) 322-328.

  • Ruthenium (II) nitrofurylsemicarbazone complexes: New DNA binding agents. E. Cabrera, H. Cerecetto*, M. González, D. Gambino*, P. Noblía, L. Otero, B. Parajón-Costa, A. Anzellotti, R. Sánchez-Delgado, A. Azqueta, A. López de Ceráin, A. Monge. European Journal of Medicinal Chemistry 39(4) (2004) 377-382.

  • In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones. G. Aguirre, L. Boiani, H. Cerecetto, M. González, A. Denicola, L. Otero, D. Gambino, C. Rigol, C. Olea-Azar, M. Faundez. Bioorganic Medicinal Chemistry 12(18) (2004) 4885-4893.

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2003

  • Synthesis and characterization of new ruthenium complexes with active ligands against Chagas’ disease. L. Otero, P. Noblía, D. Gambino*, H. Cerecetto, M. González, R. Di Maio, J. Ellena, O.E. Piro. Inorganica Chimica Acta 344 (2003) 85-94.

  • New Re(V) nitrofuryl semicarbazone complexes. Crystal structure of ReOCl2(PPh3)(3-(5-Nitrofuryl)acroleine semicarbazone]. L. Otero, P. Noblía, D. Gambino*, H. Cerecetto, M. González, R. Sanchez-Delgado, E. E. Castellano, O.E. Piro. Zeitschrift für Anorganische und Allgemeine Chemie 629 (2003) 1033-1038.

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Journal Publications
Reviews

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2018

  • Design of prospective antiparasitic metal-based compounds including selected organometallic cores. D. Gambino*, L. Otero, Inorganica Chimica Acta 472 (2018) 58-75.

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2015

  • Vanadium Compounds in Medicine. J. Costa Pessoa, S. Etcheverry, D. Gambino, Coordination Chemistry Reviews 301-302 (2015) 24-48.

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2012

  • Perspectives on what ruthenium-based compounds could offer in the development of potential antiparasitic drugs. D. Gambino*, L. Otero, Inorganica Chimica Acta Special issue Metals in Medicine 393 (2012) 103–114.

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2011

  • Potentiality of vanadium compounds as anti-parasitic agents. D. Gambino, Coordination Chemistry Reviews 255 (2011) 2193– 2203.

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2010

  • Metal based Drugs for Malaria, Trypanosomiasis and Leishmaniasis. Recent achievements and perspectives. M. Navarro, C. Gabbiani, L. Messori*, D. Gambino, Drug Discovery Today, 15 (2010) 1070-1078. 

  • Potential therapeutic applications of metal compounds directed towards hypoxic tissues. D. Gambino*. In Advances and current perspectives in Medicinal Inorganic Chemistry. Current Medicinal Chemistry 17 (2010) 3616-3631.

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2004

  • The wide pharmacological versatility of semicarbazones, thiosemicarbazones and their metal complexes. H. Beraldo, D. Gambino*. In Metal compounds in Medicinal Chemistry. Minireviews in Medicinal Chemistry 4(1) (2004) 31-40.

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Books

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2019

  • Metal compounds in the development of antiparasitic agents: rational design from basic chemistry to the clinic. D,Gambino, L.Otero in Metal Ions in Life Sciences, Volume 19. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic. Guest-edited by Peggy L. Carver. Series Editors: Astrid Sigel, Eva Freisinger and Roland K. Sigel. Walter De Gruyter Verlag, Berlin, Germany, 2019. eISSN: 1868-0402. Met. Ions Life Sci. 2019,19, 331–357.

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2018

  • Ruthenium in Medicinal Chemistry. Dinorah Gambino, Lucía Otero en: Ruthenium Chemistry, eds. Ajay Kumar Mishra and Lallan Mishra, Pan Stanford Publishing Pte. Ltd., 2018, pp. 11-44, ISBN 978-981-4774-39-0 (Hardcover), 978-1-315-11058-5 (eBook).

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2015

  • Fármacos que cambiaron el mundo: cisplatino. Dinorah Gambino, Lucía Otero en: Investigación virtual de sistemas bioinorgánicos. Una herramienta para la enseñanza de la Química, María H. Torre (ed), Editorial Académica Española. Saarbrücken, Alemania, 2015, pp. 37-58, ISBN: 978-3-659-07553-7.

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2012

  • La Química Inorgánica Médica como nueva estrategia para el desarrollo de compuestos con actividad contra Trypanosoma cruzi. D. Gambino* en Enfermedad de Chagas: Estrategias en la búsqueda de nuevos medicamentos. Una visión Iberoamericana, eds. Hugo Cerecetto y Mercedes González, ed. Laboratorios Silanes, SA de CV, México, 2012, pp. 209-226. ISBN: 978-607-95813-0-5.

  • Bio-sistemas susceptibles a metales. D. Gambino* en Enfermedad de Chagas: Estrategias en la búsqueda de nuevos medicamentos. Una visión Iberoamericana, eds. Hugo Cerecetto y Mercedes González, ed. Laboratorios Silanes, SA de CV, México, 2012, pp. 65-80. ISBN: 978-607-95813-0-5.

  • Compuestos metálicos como potenciales agentes contra la Tripanosomiasis americana  o enfermedad de Chagas. D. Gambino*, L. Otero en: Aplicaciones de compuestos metálicos en Medicina, libro red CYTED RIIDFCM, ed. D. Gambino, co-editoras M. Navarro, V. Moreno, Editorial Académica Española. Saarbrücken, Alemania, 2012, pp. 113-140. ISBN: 978-3-8484-7138-6.

  • Química Médica y Salud, autores: Marisabel Saravay, Alberto Lahore, orientadores: Dinorah Gambino, Hugo Cerecetto, evaluador: Graciela Mahler; en: Aportes de la Química al mejoramiento de la calidad de vida, libro de UNESCO proyecto “DOCENTES APRENDIENDO EN RED (DAR)”, 2012, pp. 133-161. ISBN: 978-92-9089-187-1.

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2009

  • Aportes de la Química Inorgánica Medicinal en Uruguay al desarrollo de nuevos compuestos con actividad contra Trypanosoma cruzi. D. Gambino*, L. Otero en A 100 años del Descubrimiento de la Enfermedad de Chagas. Contribuciones desde Uruguay, ed. Organización Panamericana de la Salud (Organización Mundial de la Salud, OMS), 2009, pp. 91-108. HSD/CD/550-09

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2008

  • Improving bioactive ligands´ activity through complexation with vanadium. D. Gambino* in Book of Reviews on “Vanadium Biochemistry”, ed. Manuel Aureliano Alves, Research Signpost, Kerala, India, 2008, capítulo 15, pp. 285-321. ISBN: 978-81-308-0184-1.

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